I've couple windows tools for fixing PC that came as CD image, I can write to USB to boot, or use other tools like YUMI to multi boot them, but is there any tools for easy mounting and execute ISO image within Linux, so that I can use them on my USB boot Linux, thanks !

Grub can boot iso file that's stored on your filesystem.

Or, to boot an iso file within linux itself, you need a virtual machine manager. Install virt-manager or virtualbox for that.

You can loop mount an ISO file as if it were an actual CD and execute a program. However a Windows program would only run via wine or other DOS emulator.

What type of Windows program are you trying to run and what are you trying to fix?

I got couple of disk cloning s/w such as Arconis, I know Clonezilla also work but not as straight forward as Arconis. Also paid for the Spinrite which I believe runs on a free DOS

Acronis does not work from wine nor would i expect any to work.
I would try to run spinrite from a USB with freedos.

You would mount the ISO image within Linux, and then use appropriate means to cause Wine to see it "as a drive [letter]."

Although Wine is quite useful – and amazingly interesting, if you peek under the covers – when I need to run Windows programs on Linux I simply pony-up for a Windows® license and run it in a [VirtualBox ...] virtual machine. Microsoft will sell you licenses (and downloadable ISOs) online, for what is actually a very reasonable fee. "Just buy one, use it when you have to, and be very glad that you don't have to use it most of the time."

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A virtual machine in this case is irrelevant because the OP wants to run either cloning software or disk repair software.

Grml rescue boot might work and be an option.

https://wiki.grml.org/doku.php?id=rescueboot

You should be able to put that software on a separate partition or on a Linux or windows partition and boot it. Not likely that a windows software iso file will boot directly from an iso file, it will need to be extracted first then copied to a partition. The filesystem type should not matter, vfat, ext4, ntfs. You can create a separate partition for this software or put it in a directory on another partition. What you would need then is a correct menuentry for your grub.cfg file on Linux and that is where your problem will come in as you don't seem to have much knowledge in that area. Never tried to boot Acronis or Spinrite so have no ideas there.

Thank guys for the info., I guess it would be easier to use a dedicated USB drive for all the tools instead of to run them within a Linux distro, I used YUMI to do that before with little problem.

I think my Acronis has a way to make a boot usb?? I'll have to double check.

To make one app to boot on USB no problem, but I want multiple apps I can select to run upon boot, YUMI can do that.

IMHO he no need use pure wine that's right ? Steam have proton, on Debian may use Lutris, it is very good option for run windows platform apps.