Hello again, osbiefeelgood and I'll spare you the customary welcome.
AMD & Nvidia? Not a good combination, imho. If the amd gpu is internal, that may be ok. Both AMD & Nvidia use proprietary drivers, and their own versions of/usr/lib(64)/libGL*.
Amd also has kernel drivers, and Nvidia has nouveau. For my first try, I would use
- Proprietary drivers for Nvidia
- Kernel Drivers for AMD
And report on how that goes.
From previous experience, it's difficult if not impossible to disable a built-in gpu. You can disable the Nvidia by depriving it of modules or firmware. The mistake might have been buying an AMD gpu with internal processor, because they are always uninspiring, even AMD's.
You might also explain how you have set the monitors up. Mine were 1600x900 & 1920x1080. I set them as left/right and the virtual screen was 3520(=1600+1920)x1080.