In no particular order:
- The Quest For Glory series (or at least QFG V - but works under wine it does B) )
- The King's Quest series
- The Prince of Persia games (Wine can't run this -yet- because it does not have multithreading support ATM... or something like that).
- The Longest Journey and Dreamfall (DF *almost* works with Wine)
- Secret Files Tunguska (this also works with wine... perfectly, I might add).
- Beyond Good & Evil
- TES (The Elder Scrolls): Morrowind and TES: Oblivion
- Broken Sword series (at least, Sleeping Dragon and Angel of Death)
- Two Worlds (has yet to come out - somewhere in June I think)
- Still Life
- Laxius Power series (well, those work with Wine too...)
- Anachronox (yes, Wine plays this too...)
- Gothic III
- Discworld series
- Monkey Island series
- Gabriel Knight series (Beast Within runs perfectly on Wine, I believe GK3 runs on it too)
- Grim Fandango
- Runaway I and II (what do you know, Wine runs both of these too...)
- Simon the Sorcerer series
- Sam & Max series
- Splinter Cell Series
- Deus EX 1
- The upcoming "Assassins Creed"
So far my "modest" list